Abstract:Ferroptosis is a regulatory cell death characterized by iron overload and lipid peroxidation damage and is different from the forms of cell death, such as apoptosis, necrosis and autophagy in terms of morphological and biochemical characteristics. Numerous studies have found that ferroptosis pathway is closely correlated with drug resistance in tumors. Tumor cells reduce their susceptibility to ferroptosis by down-regulating the ferroptosis pathway, leading to resistance to treatment. This article reviews the role of ferroptosis in drug resistance of tumor cells and its mechanism, in the hope of providing new ideas for the clinical treatment of tumors.