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Received:December 06, 2022 Published Online:July 19, 2023
Received:December 06, 2022 Published Online:July 19, 2023
中文摘要: 目的 分析60岁以上老年人接种新型冠状病毒疫苗(新冠疫苗)不同针次后的不良反应及对既往基础疾病的影响,探讨接种新冠疫苗的安全性及耐受性。方法 通过调查问卷及电话回访的方式,收集2021年7月至2022年7月南京江北新区接种科兴新冠灭活疫菌(Vero细胞)的60岁以上老人2 103例的基本资料,疫苗接种情况,接种后30min、1d、3d、7d、14d的不良反应及副作用。根据有无基础疾病分为对照组(无基础疾病,n=1 346)、慢性病组(有基础疾病,n=757),比较两组老年人疫苗接种后不良反应的差异及对基础疾病的影响。结果 本次调查的2 103例中仅有86例(4.09%)接种后存在一种或多种不良反应,而最常见的局部不良反应是注射部位疼痛(2.48%),最常见的全身不良反应是疲劳(0.24%),其次是发热(0.14%)和头痛(0.19%)。所有不良反应均为轻度(1级或2级)和自限性。多因素logistic回归分析示,既往是否合并基础疾病、是否吸烟、疫苗接种针次均对接种后的不良反应无影响(P>0.05)。结论 健康状况稳定、药物控制良好的60岁以上老年人群接种新冠疫苗不良反应发生率低,安全性高。
Abstract:Objective To analyze the adverse reactions of novel coronavirus vaccine (SARS-CoV-2 vaccine) and the impact on previous underlying diseases after different vaccination numbers in the elderly over 60 years old ,and to explore the safety and tolerance of SARS-CoV-2 vaccine.
Methods By means of a questionnaire survey and telephone return visit, the basic information were collected among 2103 elderly people over 60 years old who were vaccinated with Sinovac-CoronaVac vaccine(Vero cell) in Jiangbei New District of Nanjing from July 2021 to July 2022. They were divided into control group (without basic diseases, n=1346) and chronic disease group (with basic diseases, n=757) according to whether there were basic diseases or not. At 30 minutes, 1-, 3-, 7- and 14-day after vaccination, the adverse reactions and the impacts on the underlying diseases were observed and compared between two groups.
Results
Out of 2103 persons surveyed, only 86(4.09%) subjects had one or more adverse reactions after vaccination. The most common local and systemic adverse reactions were pain at the injection site(2.48%) and fatigue(0.24%), followed by fever(0.14%) and headache(0.19%). All adverse reactions were mild(grade 1 or 2) and self-limiting. Multivariate logistic regression analysis showed that previous underlying diseases, smoking and vaccination numbers had no significant impacts on adverse reactions after vaccination(P>0.05).
Conclusion The incidence of adverse reactions after SARS-CoV-2 vaccination is low, and the safety is high for the elderly over 60 years old with stable health and good drug control.
文章编号: 中图分类号:R186+.3 文献标志码:B
基金项目:国家自然科学基金面上项目(82072783)
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