Abstract:Objective To explore the expression of Vimentin, a marker of epithelial-mesenchymal transition, and its association with breast cancer specific gene 1(BCSG1) in triple negative breast cancer(TNBC). Methods Sixty female patients with TNBC who received treatment in the Third Hospital of Changsha from January 2018 to January 2020 were selected as the research subjects(research group), and 20 female patients with benign breast lesions receiving treatment at the same period were served as control group. Vimentin and BCSG1 expression in TNBC cancerous tissues and benign breast lesions were detected by qRT-PCR and immunohistochemistry. Results Vimentin and BCSG1 expression levels increased sequentially in benign breast lesion tissues (1.02±0.05, 0), non-TNB tissues (2.13±0.21, 2.16±0.23) and TNBC tissues (2.41±0.22, 2.45±0.24) (F=382.600, P＜0.01; F=1003.000, P＜0.01）. There was a positive correlation between the expression of Vimentin and BCSG1 in TNBC (r=0.370, P<0.05), and the high expressions of Vimentin and BCSG1 were the independent risk factors for the prognosis of TNBC patients (OR=13.662, P=0.035; OR=15.443, P=0.001). The sensitivity of Vimentin combined with BCSG1 for TNBC diagnosis was 92.35%, the specificity was 95.64%, and the area under the ROC was 0.891. Conclusion BCSG1 and Vimentin have a positive correlation, and their expression levels in TNBC tissues are significantly higher compared with benign breast lesions, and the combination of the two has high diagnostic efficacy for TNBC.