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Received:September 05, 2022 Published Online:June 20, 2023
Received:September 05, 2022 Published Online:June 20, 2023
中文摘要: 目的 探讨补气温阳定狂汤治疗虚阳上浮型躁狂症的疗效及对认知功能和睡眠质量的影响。 方法 选择广州医科大学附属脑科医院于2020年1月至2022年1月住院的躁狂症患者100例,依据随机数字表法分为观察组（n=50）与对照组（n=50）。对照组给予丙戊酸钠缓释片和喹硫平片治疗,观察组在对照组基础上结合补气温阳定狂汤治疗。两组治疗疗程4周。比较两组治疗疗效;治疗前与治疗4周主要症候积分,临床总体印象量表（CGI）评分,匹兹堡睡眠质量指数量表（PSQI）评分,可反复测查的成套神经心理状态评估工具（RBANS）评分;不良反应情况。 结果 观察组总有效率为90.00%,高于对照组的72.00%（χ2=5.263, P＜0.05）。两组治疗4周狂躁不安、渴不欲饮和肢冷积分低于治疗前（P＜0.05）,且观察组低于对照组（P＜0.01）。两组治疗4周BRMS量表评分、CGI评分、PSQI量表低于治疗前（P＜0.05）,且观察组低于对照组（P＜0.01）。两组治疗4周即刻记忆、空间结构、注意力、言语功能和延迟记忆评分高于治疗前,且观察组高于对照组（P＜0.01）。观察组不良反应少于对照组（8.00% vs 26.00%, P＜0.05）。 结论 补气温阳定狂汤治疗虚阳上浮型躁狂症患者疗效较好,可显著改善患者认知功能和睡眠质量。
Abstract:Objective To investigate the efficacy and effects on cognitive function and sleep quality of Buqi Wenyang Dingkuang Decoction in treatment of mania patients with upfloating of asthenia yang type. Methods A total of 100 patients with mania who were hospitalized between January 2020 and January 2022 in the Affiliated Brain Hospital of Guangzhou Medical University were selected and divided into observation group and control group according to the random number table method (n=50, each) . Both group was given valproate sustained-release tablets and quetiapine tablets treatment, and the observation group was added with Buqi Wenyang Dingkuang Decoction. The treatment course of the 2 groups was 4 weeks. Treatment efficacy and incidence of adverse reactions were compared between two groups. The primary syndrome score, Clinical Global Impressions Scale (CGI) score, Pittsburgh Sleep Quality Index (PSQI) score and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) score before and after treatment were compared between the two groups. Results The total effective rate was higher in the observation group than in the control group (90.00% vs 72.00%, χ2=5.263, P＜0.05) . The scores of mania, thirst not to drink, and limb cold at 4 weeks of treatment in the 2 groups were lower than those before treatment (P＜0.05) , and those of the observation group were lower than those of the control group (P＜0.01) . The BRMS scale score, CGI score, and PSQI scale score of the 2 groups at 4 weeks of treatment were lower than those before treatment (P＜0.01) , and the above-mentioned scores of the observation group were lower than those of the control group (P＜0.01) . The scores of immediate memory, spatial structure, attention, verbal function, and delayed memory in the 2 groups at 4 weeks of treatment were higher than those at pretreatment (P＜0.01) , and the scores in the observation group after treatment were higher than those in the control group (P＜0.05) . Fewer adverse reactions were observed in the observation group than those in the control group (8.00% vs 26.00%, P＜0.05) . Conclusion Buqi Wenyang Dingkuang Decoction has a certain effect on mania patients with upfloating of asthenia yang type, and can significantly improve their cognitive function and sleep quality.
keywords: Buqi Wenyang Dingkuang Decoction Upfloating of asthenia yang type Mania Cognitive function Sleep quality Valproate Quetiapine
文章编号： 中图分类号：R749.3 文献标志码：B
基金项目:广东省中医药局科研项目 (20211305)
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