Abstract:Objective To explore the effect of smoking cessation combined with flutamide on improving the lung function and motor function in stable chronic obstructive pulmonary disease (COPD) patients complicated with respiratory failure. Methods A retrospective study was conducted on 100 stable COPD patients complicated with respiratory failure treated from January 2020 to January 2022 at the Second People's Hospital of Liaocheng through convenience sampling and control principles. The patients who were treated with flutimevir served as the control group (n=50) , and those who were given smoking cessation combined with flutimevir served as the observation group (n=50) . The clinical efficacy, pulmonary function indexes, 6-minute walk test (6WMT) , dyspnea score ［modified Medical Research Council (mMRC) ］and serum inflammation markers were compared between two groups. Results The total effective rate in observation group was significantly higher than that in control group (94.00% vs 72.00%, P＜0.01) . After treatment, forced vital capacity (FVC) , forced expiratory volume in the first second (FEV₁) and FEV₁/FVC ratio in observation group were statistically higher than those in control group (P＜0.05) . Compared with those in control group, 6WMT increased, and mMRC score and levels of serum tumor necrosis factor-α (TNF-α) , interleukin (IL) -8 and IL-6 decreased significantly in observation group (P＜0.05) . Conclusion For the stable COPD patients complicated with respiratory failure, smoking cessation combined with flutamide can effectively improve the pulmonary function and motor function and significantly reduce the degree of dyspnea and the inflammatory response.