Abstract:Objective To summarize the clinical features, diagnosis and treatment of patients with pulmonary thromboembolism（PTE） to explore the related risk factors affecting the severity of PTE patients. Methods A retrospective analysis was performed on the clinical data of 222 PTE patients in the Affiliated Hospital of Jining Medical University from January 2019 to December 2020. According to guidelines on the diagnosis and management of acute PTE, the patients were divided into low-risk group（n=117） and medium-high-risk group（n=105）. Univariate and multivariate analysis were used to screen the relevant factors affecting the severity of PTE. Results The clinical manifestations of PTE were complex and varied. Dyspnea was the most common clinical symptom of the patients（63.06%）, and only 4.05% of patients had the triad of dyspnea, chest pain and hemoptysis simultaneously. The levels of D-dimer, C-reactive protein, white blood cell count, prothrombin time（PT）, alanine aminotransferase（ALT）, aspartate aminotransferase（AST） and blood urea nitrogen（BUN） in medium-high-risk group were significantly higher than those in low-risk group（P＜0.05）. CT pulmonary angiography（CTPA） clearly showed the incidence of lobar pulmonary artery embolism was the highest, accounting for 68.47%. The incidence of pulmonary artery trunk embolism in medium-high-risk group was significantly higher than that in low-risk group（43.81% vs 9.40%, P＜0.01）. Most PTE patients were complicated with lower limb intermuscular vein and/or deep-vein thrombosis. Anticoagulant therapy was performed in 95.50% of patients, and thrombolytic therapy was conducted in 3.15% of patients, with good prognosis. The in-hospital mortality rate was 1.35%. Logistic multivariate regression analysis showed that high pulse oxygen saturation was an independent protective factor for the severity of PTE, and high AST and BUN levels and pulmonary artery trunk embolism were the independent risk factors for the severity of PTE（P＜0.05）. Conclusion The clinical manifestations of PTE are complex and varied. Pulse oxygen saturation, AST and BUN levels and pulmonary artery trunk embolism are the independent factors affecting the severity of PTE patients.