Abstract:The ethical review of non-experimental clinical research plays an important role in the work of the institutional ethics committee. This paper analyzes the main types of non-experimental clinical research in hospitals and the characteristics and emphases of the protection of subjects' rights and interests in non-experimental clinical research. This paper puts forward a new idea of ethical review for non-experimental clinical research work, which should first determine its research nature, highlight the protection of personal privacy and strengthen the construction of public notification system. Specific measures are also proposed for the exemption of ethical review and informed consent in clinical research and teaching.