Abstract:Objective To compare the differences in serum uric acid (UA) to high-density lipoprotein cholesterol (HDL-C) ratio (UHR) and other laboratory parameters between Hashimoto's thyroiditis (HT) patients and healthy people. Methods A retrospective study was performed on 63 patients with HT confirmed by medical history, physical examination, elevated thyroid autoantibodies in serum and characteristic sonographic findings in the General Hospital of Northern Theater Command from June to September 2021 (HT group). The age- and gender-matched 106 healthy volunteers were enrolled as the control group. UHR and other laboratory parameters were compared between two groups. Results UHR in HT group was significantly higher than that in control group (0.41±0.13 vs 0.30±0.07, P<0.01). UHR was positively correlated with thyroid stimulating hormone (TSH) level (r=0.15,P=0.049) and was negatively correlated with free T4 (FT4) level (r =-0.38,P<0.01). UHR greater than 37.5% had 78% sensitivity and 80% specify in predicting Hashimoto's thyroiditis (AUC=0.79,95%CI: 0.707-0.868,P<0.01). Conclusion UHR is a reliable and useful marker of HT and may be helpful to establish the diagnosis of Hashimoto's thyroiditis.