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Received:June 29, 2022 Published Online:March 20, 2023
Received:June 29, 2022 Published Online:March 20, 2023
中文摘要: 目的 探讨125I放射性粒子植入治疗联合化疗对复发性宫颈癌的疗效。方法 选择2015年1月至2019年12月在黄石市中心医院接受治疗的复发型宫颈癌患者95例作为研究对象,根据治疗方式的不同,将患者分为试验组(50例)和对照组(45例),对照组给予序贯化疗,试验组在对照组的基础上,在完成4个化疗疗程(4×21 d)结束7 d后,给予患者125I放射性粒子植入治疗联合紫杉醇、顺铂序贯化疗治疗。于试验组125I粒子植入后30 d,评价并对比两组临床疗效,分析两组治疗后的体力、体质量、疼痛感改善情况,生命质量核心量表评分情况,以及并发症发生情况。治疗后的体力、体质量、疼痛感改善情况,生命质量核心量表评分情况,以及并发症发生情况。结果 试验组总有效率和局部控制率均高于对照组(P<0.05)。试验组治疗后患者的体力、体质量、疼痛感减轻均显著优于对照组(P<0.01)。治疗后,两组QLQ-C30各项评分优于治疗前,且试验组均优于对照组,差异有统计学意义(P<0.01)。试验组放射性皮炎、骨髓抑制、消化道反应发生率均显著低于对照组,差异有统计学意义(P<0.01)。结论 125I放射性粒子植入治疗联合化疗治疗复发性宫颈癌能够有效提升患者的治疗效果及临床受益率,改善患者的生活质量,不增加并发症及不良反应的发生率。
Abstract:Objective To investigate the effect of 125I radioactive seeds implantation combined with chemotherapy on recurrent cervical cancer. Methods Ninety-five patients with recurrent cervical cancer treated in Huangshi Central Hospital from January 2015 to December 2019 were selected and were divided into experiment group (n=50) and control group (n=45) according to the different treatment methods. The sequential chemotherapy of paclitaxel and cisplatin was given in control group, and Seven days after completing four courses of chemotherapy (4×21 d),125I radioactive seeds implantation combined with chemotherapy was conducted in experimental group. On 30 days after the implantation of 125I seeds in experimental group, the clinical efficacy of the two groups was evaluated and compared, and the improvement of physical strength, body mass, pain sensation, quality-of-life core questionnaire (QLQ-C30) and the incidence of complications were analyzed. Results The total effective rate and the local control rate in experiment group were significantly higher than those in control group (P<0.05). The improvement of physical strength, body mass and pain in experiment group were significantly better than those in control group (P<0.01). After treatment, the scores of QLQ-C30 were significantly superior to those before treatment in both groups and were better in experiment group than those in control group (P<0.01). The incidences of radiation dermatitis, bone marrow suppression and gastrointestinal reaction in experimental group were significantly lower than those in control group (P<0.05). Conclusion 125I radioactive seeds implantation combined with chemotherapy can significantly improve the therapeutic efficacy and the quality of life and reduce the incidence of complications in the patients with recurrent cervical cancer.
文章编号: 中图分类号:R737.33 R730.55 文献标志码:B
基金项目:湖北省卫生健康委员会联合基金项目(WJ2019H460)
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