Abstract:Objective To investigate the impacts of donepezil hydrochloride or nimodipine combined with butylphthalide on cerebral blood flow changes, cognitive function and neuroelectrophysiology in patients with vascular dementia (VD). Methods The VD patients treated between May 2020 and December 2021 were selected and divided into observation group (n=51, using butylphthalide with donepezil hydrochloride) and control group (n=51, using butylphthalide with nimodipine). The changes of cerebral blood flow ［mean transit time (MTT), cerebral blood flow (CBF), cerebral blood volume (CBV)］, mini-mental state examination scale (MMSE), clinical dementia rating (CDR) and neurophysiological indicators ［P300 latency, P300 amplitude, (δ+θ)/ (α+β) ratio］ were observed and compared between two groups. Results Before treatment, there was no significant difference in MTT, CVB, CBF, MMSE score, CDR score, P300 latency, P300 amplitude and (δ+θ)/ (α+β) ratio between two groups (P＞0.05). After treatment, MMSE scores, P300 amplitude, CVB and CBF in observation group were significantly higher than those in control group (P＜0.05), while CDR scores, P300 latency, (δ+θ)/ (α+β) ratio and MTT were lower than those in control group (P＜0.05). There was no significant difference in the total incidence of adverse reactions between two groups (P＞0.05). Conclusion In the treatment of vascular dementia, butylphthalide combined with donepezil hydrochloride is more effective than butylphthalide combined with nimodipine, and can significantly improve the cognitive function and cerebral blood perfusion in the patients.