Abstract:Objective To investigate the effect of early intensive antihypertensive therapy on hematoma expansion and prognosis in patients with acute hypertensive intracerebral hemorrhage. Methods A total of 88 patients with acute hypertensive intracerebral hemorrhage admitted to the First Affiliated Hospital of Soochow University from January 2020 to August 2021 were selected and divided into intensive antihypertensive group and target antihypertensive group randomly (n=44, each). The intracranial hemorrhage volume and Glasgow Coma Scale (GCS) before and after treatment were compared between the two groups. Results After 24 hours of treatment, the volume of intracranial hemorrhage in the intensive antihypertensive group was lower than that in the target antihypertensive group ［10.57 (2.25,13.43) ml vs 13.35 (5.59,22.78) ml, Z=2.337, P=0.019］. Analysis of variance for repeated measurement data showed that the time effect and inter group effect of GCS scores before and after treatment in the two groups were significant (F=26.968, P＜0.01;F=34.809, P＜0.01). But there was no interaction between time and grouping (F=1.091, P=0.355). Conclusion Intensive antihypertensive therapy can reduce the risk of hematoma expansion and help improve the prognosis of hypertensive intracerebral hemorrhage patients.