Abstract:ObjectiveTo investigate the diagnostic value of Mycoplasma pneumoniae IgM antibody(MP-IgM), procalcitonin(PCT) and hypersensitive C-reactive protein(hs-CRP) combined detection in children with Mycoplasma pneumoniae infection. MethodsFifty-eight children with Mycoplasma pneumoniae infection in Nanjing Jiangbei Hospital from August 2022 to December 2022 were selected as the infection group, and 59 healthy children in the same period were selected as the control group. The diagnostic value of combined detection of hs-CRP, PCT and MP-IgM in children with Mycoplasma pneumoniae infection was compared and analyzed. ResultsCompared with the control group, the levels of PCT and hs-CRP in the infection group were higher than those in the control group(P＜0.05). The positive rate of MP-IgM in the infection group was higher than that in the control group (75.9% vs10.2%, P＜0.05). The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of MP-IgM in the diagnosis of MP infection were 75.9%, 89.8%, 88.0%, 79.1% and 82.9%, respectively. The area under the curve(AUC) of PCT and hs-CRP were 0.672 and 0.640 respectively when analyzed by ROC curve. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of combined detection of PCT and hs-CRP with MP-IgM were 91.3%, 88.1%, 88.3%, 91.1% and 89.7% respectively. ConclusionsPCT and hs-CRP have certain application value in the diagnosis of Mycoplasma pneumoniae infection in children. The combination of PCT and hs-CRP with traditional MP-IgM detection can effectively improve the positive rate of detection. The sensitivity, negative predictive value and accuracy of the combined detection are higher than that of single MP-IgM detection, which can make up for the deficiency of the positive rate of pure MP-IgM detection.