Abstract:ObjectiveTo explore the risk factors of mortality for children with Streptococcus pneumococcal meningitis. MethodsA retrospective analysis was conducted on the clinical data of 41 hospitalized children diagnosed as Streptococcus pneumoniae menigitis in Jiangxi Children‘s Hospital from January 2016 to December 2018. According to the prognosis of disease, the patients were divided into the death group (n=10) and the survival group (n=31). The clinical characteristics, laboratory indicators and treatment effect were compared between two groups, and the risk factors of mortality were analyzed by multivariate logistic regression analysis. ResultsThe case fatality rate of Streptococcus pneumoniae menigitis was 24.4%. The proportions of convulsions, platelet count<100×10⁹/L, serum lactate dehydrogenase concentration ＞500 U/L, cerebrospinal fluid protein level more than 3 g/L and mechanical ventilation in death group were significantly higher than those in survival group (P<0.05). The univariate analysis showed that convulsions, platelet count<100×10⁹/L, high levels of lactate dehydrogenase(>500 U/L) and cerebrospinal fluid (>3 g/L) and undergoing mechanical ventilation were the influencing factors of the death for children with Streptococcus pneumoniae menigitis. Multivariate analysis showed that high level of lactate dehydrogenase (>500 U/L, OR=27.874, 95%CI：1.253-619.966) and mechanical ventilation (OR=30.591, 95%CI：1.097-853.089) were the risk factors for the death in children with PM (P<0.05). ConclusionThe mortality of Streptococcus pneumoniae meningitis is high. Lactate dehydrogenase level ＞500 U/L and mechanical ventilation are the risk factors for death in children with Streptococcus pneumoniae menigitis.