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Received:April 02, 2022 Published Online:February 20, 2023
Received:April 02, 2022 Published Online:February 20, 2023
中文摘要: 目的 探讨血清中影响组织纤维化的乳脂球表皮生长因子-8(MFG-E8)的水平与患者心房颤动(房颤)发生的相关性。方法 收集2021年1月至12月淮安市中医院收治的非瓣膜性房颤老年患者58例,依据房颤发作特点分为阵发性房颤组、持续性房颤组,各29例;另选取同期住院窦性心律患者29例,测定三组研究对象血清MFG-E8、总胆固醇(TC)、三酰甘油(TG)、载脂蛋白A(apoA)、载脂蛋白B(apoB)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、超敏C反应蛋白(hs-CRP)水平及左心房内径(LAD),并进行比较。结果 阵发性房颤组、持续性房颤组MFG-E8水平显著低于窦性心律组,LAD、hs-CRP水平显著高于窦性心律组,差异有统计学意义(P<0.01)。Pearson相关性分析显示,房颤患者的LAD与MFG-E8成负相关(r=-0.631,P<0.05),与hs-CRP成正相关(r=0.593,P<0.05)。二元logistic回归分析显示,MFG-E8、LAD、hs-CRP为房颤发生的独立影响因素(OR=0.978、2.109、19.102,P<0.01)。结论 影响房颤发生与进展的心房纤维化进程中,MFG-E8水平与房颤的发生与维持呈负相关,可以作为预测房颤发生进展的指标。
中文关键词: 乳脂球表皮生长因子-8 心房颤动,非瓣膜性 心房纤维化 超敏C反应蛋白
Abstract:ObjectiveTo investigate the correlation between the serum level of milk fat globule-epidermal growth factor 8(MFG-E8) and the occurrence of atrial fibrillation(AF) in patients. MethodsFrom January 2021 to December 2021, 58 elderly patients with non-valvular AF admitted to Huaian Hospital of Chinese Medicine were selected and divided into paroxysmal AF group and persistent AF group(n=29, each), and 29 sinus rhythm inpatients were served as controls(sinus rhythm group) at the same period. The serum levels of MFG-E8, total cholesterol(TC), triglycerides(TG), apolipoprotein A(apoA), apolipoprotein B(apoB), low-density lipoprotein cholesterol(LDL-C), high-density lipoprotein cholesterol(HDL-C) and hypersensitivity C-reactive protein(hs-CRP) and the left atrial diameter(LAD) were measured and compared among three groups. ResultsCompared with those in sinus rhythm group, the levels of MMG-E8 significantly decreased, and the levels of LAD and hs-CRP increased in paroxysmal AF and persistent AF groups(P<0.01). Pearson correlation analysis showed that LAD was negatively correlated with MFG-E8 and positively correlated with hs-CRP in AF patients(P<0.05). Binary logistic regression analysis showed that MFG-E8, LAD and hs-CRP were the independent predictors of AF 〖JP2〗attacks(OR=0.978, 2.109, 19.102, P<0.01). ConclusionIn the process of atrial inflammatory fibrosis, MFG-E8 was negatively correlated with the occurrence and maintenance of AF and can be used as a prediction index of AF.
keywords: Milk fat globule-epidermal growth factor 8 Atrial fibrillation, non-valvular Atrial fibrosis Hypersensitivity C-reactive protein
文章编号: 中图分类号: 文献标志码:B
基金项目:江苏省淮安市卫生健康科研项目(HAWJ202024)
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