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Received:April 08, 2022 Published Online:February 20, 2023
Received:April 08, 2022 Published Online:February 20, 2023
中文摘要: 随着对恶性肿瘤治疗的重大改进,患者的长期生存率显著提高。放射治疗在胸部肿瘤(包括乳腺癌、肺癌、食管癌和霍奇金淋巴瘤)的治疗中具有重要作用。放射治疗目的是杀死肿瘤细胞。然而,治疗肿瘤的同时不可避免的会对周围正常组织产生副作用。胸部放射治疗所致的心血管不良反应综合征被称为放射性心脏病(RIHD),发生RIHD的风险是当前肿瘤学实践中的一个关键问题。RIHD的潜在机制尚不完全清楚,缺乏具体的治疗干预措施。本文就RIHD的历史、现状、病理变化及防治措施作一综述。
Abstract:The long-term survival rate of malignant tumor patients has increased significantly with the treatment improvements. Radiotherapy plays an important role in the treatment of chest tumors, including breast cancer, lung cancer, esophageal cancer and Hodgkin lymphoma. The purpose of radiotherapy is to kill tumor cells; however, it is inevitable to have side effects on the surrounding normal tissues while treating tumors. The cardiovascular adverse reaction syndrome caused by chest radiotherapy is called radiation-induced heart disease (RIHD). The risk of developing RIHD is a key issue in current oncology practice. The underlying mechanisms of RIHD are not fully understood, and specific therapeutic interventions are lacking. This article reviews the history, current situation, pathological changes, and prevention and treatment measures of RIHD.
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基金项目:国家自然科学基金(81860047);甘肃省科技计划项目(20YF3WA011)
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