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Received:June 08, 2022 Published Online:February 20, 2023
Received:June 08, 2022 Published Online:February 20, 2023
中文摘要: 目的 探讨术前外周血血小板与单核细胞比值（PMR）在结肠癌患者预后中的临床意义。方法 回顾性收集江苏大学附属武进医院2015年3月至2019年1月经手术切除且病理诊断为结肠癌的167例患者的术前外周血血常规指标、临床病理资料，分析PMR与结肠癌患者临床病理特征的关系。运用Cox风险回归模型分析PMR与结肠癌患者预后的关系。结果 不同性别、年龄的患者PMR差异有统计学意义（P＜0.05）。二元logistic单因素分析结果显示PMR、淋巴结转移、TNM分期、分化程度与结肠癌患者的总生存期相关（P＜0.05）。Cox风险回归分析显示PMR、淋巴结转移、TNM分期、分化程度为结肠癌患者预后的独立影响因素（P＜0.05）。结论 术前外周血PMR可能成为评价结肠癌患者预后的重要指标。
Abstract:ObjectiveTo investigate the clinical significance of platelet-to-monocyte ratio (PMR) in prognosis of colon cancer patients. MethodsPreoperative peripheral blood routine indicators and clinicopathological data of 167 patients with surgical resection and pathological diagnosis of colon cancer from March 2015 to January 2019 in Wujin Hospital Affiliated to Jiangsu University were retrospectively collected. The relationship between PMR and clinicopathological characteristics of colon cancer patients, and Cox regression was used to analyze the relationship between PMR, clinicopathological features and prognosis of colon cancer patients. ResultsThe PMR of patients with different genders and ages had statistically significant difference(P<0.05). Binary logistic univariate analysis showed that PMR, lymph node metastasis, TNM stage and degree of differentiation were correlated with overall survival of colon cancer patients (P<0.05). Cox regression analysis showed that PMR, lymph node metastasis, TNM stage and differentiation degree were independent prognostic factors for colon cancer patients(P<0.05). ConclusionPreoperative PMR in peripheral blood may be an important indicator of prognosis in patients with colon cancer.
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基金项目:国家自然科学基金面上项目（81872275）；江苏省卫生健康委科研项目（M2020002）；江苏省常州市科技局应用基础研究计划项目（CJ20200004，CJ20210015）
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