Abstract:Objective To explore the therapeutic effect of Gegen Qinlian Decoction on damp-heat type coronary atherosclerotic heart disease(CHD) with angina pectoris and its influence on intestinal flora. Methods From January 2020 to May 2022, 118 patients with damp-heat type stable CHD with angina pectoris hospitalized in Nanjing Jiangbei Hospital were included and divided into control group and study group randomly(n=59, each). The patients in the control group were treated with atorvastatin+placebo, and the patients in the study group were treated with atorvastatin+Gegen Qinlian Decoction. Both groups were treated for 12 weeks. The curative effect, blood lipid level and intestinal flora distribution before and after treatment were compared between the two groups. Results The total effective rate of the study group was higher than that of the control group(84.75% vs 64.41%, P=0.011). The levels of TC, TG and LDL-C in the two groups decreased significantly after treatment, while the levels of HDL-C increased. After treatment, the levels of TC, TG and LDL-C in the study group were significantly lower than those in the control group, and the level of HDL-C was significantly higher than that in the control group(P＜0.05). After treatment, the levels of Lactobacillus and Bifidobacteria increased in both groups, while the levels of Escherichia coli and Enterococcus decreased significantly, and compared with the control group, the levels of Bifidobacteria in the study group were higher, while the levels of Escherichia coli and Enterococcus were lower(P＜0.05). Conclusion Gegen Qinlian Decoction can improve the symptoms of patients with damp-heat rype CHD with angina pectoris, regulate the blood lipid levels and intestinal flora.