Abstract:Objective To analyze the pregnancy outcome of pregnant women infected with human immunodeficiency virus(HIV), so as to provide a basis for improving the measures to block HIV infection from mother to child and eliminating HIV transmission from mother to child. Methods Clinical data of 41 HIV infected pregnant women admitted to Nanjing Second Hospital from January 2017 to December 2020 was collected. The pregnancy outcomes, blocking measures during pregnancy and childbirth, maternal and infant complications, and clinical effects of maternal and infant blocking were analyzed. Results There were 11(26.83%) HIV infected pregnant women chose to terminate their pregnancy. Thirty cases(73.17%) chose to continue their pregnancy to delivery, and they were intervened with HIV maternal and infant blocking, and treated with antiretroviral drugs as early as possible. Among them, 21 cases(70.00%) took zidovudine(AZT)+lamivudine(3TC)+lopinavir/ritonavir(LPV/r), and 9 cases(30.00%) took AZT+3TC+efviren(EFV). Cesarean section was performed in 28 cases(93.33%) and vaginal delivery in 2 cases(6.67%). There was no serious complication. There were 30 live born infants, with a newborn weight of 1 790-3 600(2 876.00±556.71) g, 28 cases with Apgar score of 9-10 points and 2 cases with Apgar score of 7-9 points after birth. Blocked infants were given antiviral drugs and artificial feeding. Among them, 19 cases(63.33%) took AZT, and 11 cases(36.67%) took nevirapine. The follow-up rate of infants was 100%. There were 30 infants older than 18 months and the detection rate of early diagnosis was 100%. There was no infant with positive nucleic acid detection at early stage, and no infant with positive HIV antibody detection at 18 months. The transmission rate of HIV from mother to child was 0, and the success rate of mother to child block was 100%. There was no obvious abnormality in the growth and development of the follow-up infants. Conclusion Early use of antiretroviral drugs for HIV infected pregnant women, safe midwifery, blocking the use of antiretroviral drugs and artificial feeding of children can effectively reduce mother to child transmission of AIDS, which is an important measure to control children's AIDS.