Abstract:Objective To investigate the long-term prognosis of patients undergoing cardiac resynchronization therapy（CRT） by implantation of left ventricular electrode implantation with guidewire retention technique. Methods The patients with dilated cardiomyopathy who received pacemaker/defibrillator（CRT-P/D） implantion in Wuhan Asian Heart Hospital from February 1, 2008 to December 31, 2016 were included, and the clinical data and follow-up data of the patients who had left ventricular electrode implanted with wire retention technology were retrospectively analyzed. Left ventricular electrode parameters, chest X-ray, transthoracic echocardiography, response to treatment and prognosis were recorded. 〖KG(-2x〗Results A total of 10 patients were included in the study, followed up for 3.2 to 13.4 years, with a median follow-up of 10 years. Seven patients had CRT super-reaction. One patient died of heart failure. Of the 8 cases who completed the full follow-up, 3 patients received CRT replacement with stable left ventricular pacing threshold; the guidewire was broken in 5 patients, all of which were located in the left subclavian region, and 4 of them were implanted with new electrodes to restore resynchronization therapy. No serious complication such as venous perforation, cardiac perforation, pericardial tamponade, pleural effusion and pneumothorax occurred. Conclusion In CRT-P/D implantation, the guidewire retention can stabilize the left ventricular electrode and reduce the risk of dislocation. The guidewire breakage rate is high during long-term follow-up, but there is no serious complication. The long-term prognosis of patients is good.