Abstract:ObjectiveTo explore the application of targeted cluster nursing in preventing lung infection of inpatients in intensive care unit(ICU). Methods A total of 80 ICU inpatients in the Third Affiliated Hospital of Anhui University of Chinese Medicine from July 2017 to July 2019 were selected and randomly divided into observation group and control group(n=40, each). The routine nursing was given in control group, while targeted cluster nursing and strengthen respiratory tract management was performed in observation group. The continuous nursing intervention was conducted until the patients were discharged from ICU or died. The incidences of pulmonary infection and adverse events were observed. Lung infection time, ICU stay time and the nursing quality was recorded in two groups. Ten medical staff participating in targeted cluster nursing were randomly selected for professional skill assessment before and after the implementation to observe their professional development. Results The incidences of lung infection(10.00% vs 27.50%) and adverse events(7.50% vs 25.00%) in observation group were significantly lower than those in control group(P＜0.05). The pulmonary infection time and the ICU stay time in observation group were statistically shorter than those in control group(P＜0.01). The nursing quality in observation group was superior to that in control group(P＜0.05). The theoretical nursing knowledge and operational skills were improved to some extent in 10 recruited nurses(P＜0.05, P<0.01). Conclusion Targeted cluster nursing can improve the overall quality of care for ICU patients, shorten the time of lung infection and ICU stay and reduce the incidences of lung infection and adverse events.