Abstract:Recurrent spontaneous abortion(RSA) refers to 3 or more fetal loss before 28 weeks of gestation. Currently, it is considered that the occurrence of 2 consecutive abortions should be valued and evaluated.The pathogenesis of RSA is relatively complex. Currently known etiology includes epidemiological factors, abnormal uterine structure, prethrombotic state(also known as embolism), genetic factors, endocrine factors, infectious factors, immune factors, and other factors(such as adverse environmental factors, stress factors, etc.), but 50%-60% of cases cannot be explained.In recent years, the relationship between RSA and prethrombotic state has become a research hotspot at home and abroad. Hereditary thrombotic syndrome includes deficiency of protein C, protein S and antithrombin Ⅲ、the coagulation factor V gene mutation， HHcy， MTFHR gene mutation, prothrombin gene mutation， abnormal coagulation factor, etc.The association between inherited thrombophilias and RSA is controversial. Some experts suggest that screening for hereditary embolism and anticoagulant therapy can improve pregnancy outcomes to some extent. This article reviews the research progress on the relationship between RSA and hereditary thrombophilia.