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Received:March 18, 2022 Published Online:September 20, 2022
Received:March 18, 2022 Published Online:September 20, 2022
中文摘要: 目的 探讨慢性阻塞性肺疾病(COPD)稳定期患者发生急性脑梗死的预测因素。方法 选取2016年1月至2020年12月淮安市第一人民医院收治的COPD稳定期发生急性脑梗死患者60例为病例组,同期COPD稳定期未发生急性脑梗死患者90例为对照组,收集两组患者的基本临床资料和入院后24 h内静脉血相关化验指标,对两组数据进行统计学分析。结果 两组患者在年龄、糖尿病病史、吸烟史、白细胞、红细胞分布宽度 (RDW)、单核细胞、凝血酶原时间、红细胞、血红蛋白、红细胞压积、红细胞平均血红蛋白浓度等指标上差异有统计学意义(P<0.05, P<0.01)。logistic回归分析显示RDW、单核细胞、糖尿病病史与COPD稳定期患者的脑梗死发生具有相关性,三个因素受试者工作特征曲线 (ROC)曲线下面积为分别为0.770、0.607、0.575,敏感度分别为63.3%、58.3%、21.7%,特异度分别为80.0%、58.9%、93.3%。结论 在本研究的诸多预测因素中,RDW对COPD稳定期患者发生急性脑梗死的预测价值最高,可为此类患者的早期识别、早期干预提供一定的临床依据。
Abstract:Objective To investigate the predictive factors of acute cerebral infarction in patients with stable chronic obstructive pulmonary disease (COPD).Methods From January 2016 to December 2020, 60 patients with acute cerebral infarction in stable COPD in Huai'an First People's Hospital were selected as the case group, and 90 patients without acute cerebral infarction in stable COPD in the same period were selected as the control group. The basic clinical data of the two groups and the related laboratory indicators of venous blood within 24 hours after admission were collected and statistically analyzed. Results There were significant differences between the two groups in age, history of diabetes, smoking history, white blood cells count, red blood cell distribution width (RDW), monocytes count, prothrombin time, red blood cell count, hemoglobin, hematocrit and mean hemoglobin concentration of red blood cells (P<0.05, P<0.01). Logistic regression analysis showed that RDW, monocytes count and history of diabetes were correlated with the occurrence of cerebral infarction in patients with stable COPD. The areas under ROC of the three factors were 0.770, 0.607 and 0.575, respectively. The sensitivity was 63.3%, 58.3% and 21.7% respectively, and the specificity was 80.0%, 58.9% and 93.3% respectively. Conclusion Among many predictive factors in this study, RDW has the highest predictive value for acute cerebral infarction in patients with stable COPD, which provides a certain clinical basis for early identification and early intervention of such patients.
keywords: Acute cerebral infarction Chronic obstructive pulmonary disease Red blood cell distribution width Risk factor
文章编号: 中图分类号:R563 R743.32 文献标志码:B
基金项目:国家自然科学基金青年科学基金项目(81701290)
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