本文已被:浏览 554次 下载 345次
Received:December 15, 2021 Published Online:September 20, 2022
Received:December 15, 2021 Published Online:September 20, 2022
中文摘要: 癫痫持续状态是一种常见的神经系统急症,起病急,发作类型复杂,延误治疗极易导致预后不良。目前临床研究的重点是在院前急救中早期中止癫痫发作,但癫痫持续状态的病因尚未完全明确。药物治疗是其主要方式,一线治疗药物为苯二氮?类,但其中并没有某一种是绝对优选,而对于苯二氮?类耐药的癫痫持续状态,通常会加用一种或几种抗癫痫药物,但是各类抗癫痫药物中亦无绝对优选,而在上述两种处理后仍无法中止癫痫时,需尽快使用麻醉剂并转入重症监护室;持续24 h以上的癫痫持续状态的研究尚留有空白。对于改善癫痫持续状态的预后,早期识别和对抗癫痫药物疗效的进一步研究将是关键,本文针对癫痫持续状态的急诊药物治疗的相关研究及进展作一简要综述。
Abstract:Status epilepticus is a common neurological emergency with rapid onset and complex seizure types, and delayed treatment can easily lead to a poor prognosis. The current clinical research focuses on early termination of epileptic seizures in pre-hospital first aid, but the etiology of status epilepticus is not completely clear. Drug treatment is the main method, and the first-line drugs are benzodiazepines, but none of them is absolutely preferred. For benzodiazepine-resistant status epilepticus, one or more antiepileptic drugs are usually used, but there is also no absolute preference among various antiepileptic drugs. When the seizures cannot be stopped after the above treatments, anesthetic should be used as soon as possible and the patient should be transferred to intensive care unit. There are still gaps in the study of status epilepticus lasting more than 24 hours. To improve the prognosis of status epilepticus, early identification and further research on the efficacy of antiepileptic drugs will be the key. This article briefly reviews the research and progress of emergency drug treatment of status epilepticus.
文章编号: 中图分类号:R971+.6 文献标志码:A
基金项目:国家自然科学基金(82001380)
引用文本: