Abstract:Status epilepticus is a common neurological emergency with rapid onset and complex seizure types, and delayed treatment can easily lead to a poor prognosis. The current clinical research focuses on early termination of epileptic seizures in pre-hospital first aid, but the etiology of status epilepticus is not completely clear. Drug treatment is the main method, and the first-line drugs are benzodiazepines, but none of them is absolutely preferred. For benzodiazepine-resistant status epilepticus, one or more antiepileptic drugs are usually used, but there is also no absolute preference among various antiepileptic drugs. When the seizures cannot be stopped after the above treatments, anesthetic should be used as soon as possible and the patient should be transferred to intensive care unit. There are still gaps in the study of status epilepticus lasting more than 24 hours. To improve the prognosis of status epilepticus, early identification and further research on the efficacy of antiepileptic drugs will be the key. This article briefly reviews the research and progress of emergency drug treatment of status epilepticus.