Abstract:Intravenous thrombolysis is an effective treatment for patients with acute ischemic stroke (AIS) within the onset time window. With the development of neuroimaging technology, the detection rate of cerebral small vessel disease(CSVD）is higher in AIS patients. Related studies have shown that CSVD can increase the risk and poor outcome of hemorrhage following thrombolytic therapy for AIS, but there has not yet been a unified conclusion at present.Focusing on the subtypes of CSVD and the total illness burden, this paper reviews the research progress of hemorrhage transformation and clinical prognosis in AIS patients after intravenous thrombolysis.