Abstract:Objective To explore the impacts of warming meridian and dispelling cold method combined with mecobalamin tablets on the treatment of diabetic peripheral neuropathy（DPN） and serum cystatin C（Cys-C） level. Methods A prospective analysis was performed on 180 DPN patients （Yang Deficiency and Cold Coagulation Syndrome） hospitalized in Beijing Hospital of Traditional Chinese Medcine between January 2018 to October 2021. According to the order of hospital admission,the patients were randomly divided into observation group and control group（n=90,each） by random numbers generated from SAS 9.4 software. Based on conventional therapy of diabetes, the mecobalamin tablets were used in control group,and warming meridian and dispelling cold (Mahuang Fuzi Xixin Decoction) combined with mecobalamin tablets were given in observation group. At 2 and 4 weeks after treatment,the ankle brachial index（ABI）,Toronto clinical scoring system（TCSS）, Neuropathy Total Symptom Score-6（NTSS-6）, serum homocysteine（Hcy）, Cys-C, nerve conduction velocity and disease-remission rate were compared between two groups. Results After treatment, TCSS score, NTSS-6 score, Hcy, Cys-C levels and nerve conduction velocity were improved in both groups. In observation group, TCSS score, NTSS-6 score, Hcy, and Cys-C were significantly lower than those in control group（P＜0.05）, ABI was higher than that in control group（P＜0.05）, and the improvements of sensory nerve conduction velocity（SNCV） and motor nerve conduction velocity（MNCV） of tibial nerve and peroneal nerve were superior to those in control group at 2 and 4 weeks after treatment（P＜0.05）. The disease-remission rate in observation group was statistically higher than that in control group at 1-, 2- and 4-week after treatment（P＜0.05，P<0.01）. Conclusion For the patients with DPN, warming meridians and dispersing cold combined with mecobalamin tablets has a remarkable therapeutic effect and can promote the recovery of nerve conduction velocity and improve of clinical symptoms.