Abstract:Objective To summarize the intraoperative coordination and fine care of endoscopic submucosal dissection (ESD) for the treatment of precancerous lesions and early cancer of hypopharynx and upper esophagus. Methods A retrospective analysis was performed on the clinical nursing data of 8 patients with precancerous lesions and early cancer of hypopharynx and upper esophagus receiving ESD in the Affiliated Hospital of Nanjing University of Chinese Medicine from February 2017 to November 2021 ［2 females and 6 males, aged （66.75±6.36） years］. Before operation, nursing focused on assisting preoperative evaluation, diet and medication guidance and equipment preparation. During the operation, in addition to assisting in anesthesia, endotracheal intubation, body position and endoscopy, nursing focused on the rapid exchange of instruments according to the operator’s instructions to realize the timely alternation of stripping, hemostasis and injection for lesion-lifting until the large lesion was completely removed. After operation, nursing focused on keeping the patient’s respiratory tract unobstructed, closely monitoring vital signs, preventing complications and doing a good job in comprehensive nursing. Results The operation process was smooth in 8 patients, and ESD was successfully completed at one time, without fault in nursing cooperation during operation. The rate of curative resection was 100%. Nursing interventions were effective for the patient’s pain score evaluation (3 points), out-of-bed activities and the satisfaction degree of patients and their families (100%). No serious complications occurred after surgery. Conclusion In the treatment of precancerous lesions and early cancer of hypopharynx and upper esophagus by ESD, intraoperative close cooperation and fine nursing are the important links to the success of operation and the safe rehabilitation of patients.