Abstract:Objective To exlpore the effect of ultrasound-guided lumbosacral plexus block (UGLPB) combined with general anesthesia in elderly patients with hip arthroplasty. Methods A total of 84 elderly patients who underwent hip arthroplasty in Nanchong Central Hospital from February 2019 to January 2021 were selected and divided into control group (n=42, with general anesthesia) and observation group (n=42, with UGLPB and general anesthesia) randomly. The general operation conditions, stress reaction indexes, hemodynamic parameters, brain injury indexes and adverse reactions were compared between two groups. Results In observation group, the dosage of sufentanil was significantly less than that in control group ［（15.03±4.18）ml vs（31.95±7.82）ml］, and the postoperative extubation time ［（17.11±1.82）min vs（14.29±2.85）min］ and exhaust time ［（13.54±2.63）h vs（21.06±3.57）h］ were shorter than those in control group (P<0.01). The levels of blood glucose and C-reactive protein after operation were significantly higher than those before operation in two groups, however, they were statistically lower in observation group than those in control group (P<0.01). There were significant differences in mean arterial pressure and heart rate between two groups (P<0.01). After operation, the levels of S100 β and neuron-specific enolase (NSE) were significantly higher than those before operation in two groups, but they were lower in observation group than those in control group（P<0.01）. There were 3 cases (7.14%) showing adverse reactions in control group and 2 cases (4.76%) in observation group, without significant difference in it (P>0.05). Conclusion Compared with general anesthesia alone, UGLPB combined with general anesthesia can reduce the dosage of sufentanil and the fluctuation of hemodynamic parameters, stress reaction indexes and brain injury indexes and shorten the extubation time and exhaust time with good safety in elderly patients receving hip arthroplasty.