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Received:December 28, 2021 Published Online:June 20, 2022
Received:December 28, 2021 Published Online:June 20, 2022
中文摘要: 目的 探讨肿瘤异常糖链糖蛋白（TAP）、癌胚抗原(CEA)、糖链抗原 (CA)19-9对结直肠癌诊断的价值。方法 选取2018年12月至2021年12月苏州市立医院121例经手术切除的结直肠癌患者为试验组，同期124例健康体检者为对照组，比较两组患者外周血中TAP、CEA、CA19-9的水平，按肿瘤TNM分期分类统计试验组中三者的阳性率，绘制受试者工作特征曲线（ROC）比较TAP、CEA、CA19-9单独及联合检测对结直肠癌的诊断价值。结果 试验组TAP、CEA、CA19-9阳性率及水平均高于对照组，差异有统计学意义（P＜0.01）；试验组TAP总阳性率（76.03%）高于CEA（46.28%）及CA19-9（21.49%）（P<0.01）；不同分期患者TAP阳性率分别明显高于相应分期的CEA及CA19-9的阳性率，同时，Ⅱ期患者CEA阳性率高于CA19-9阳性率（P<0.05）；TAP的ROC曲线下面积（AUC）［0.930 （95%CI:0.897~0.964）］分别高于CEA［0.795（95%CI:0.740~0.850）］及CA19-9［0.642（95%CI:0.572~0.711）］；TAP+CEA两者联合检测与TAP+CEA+CA19-9三者联合检测时AUC最高，均为0.953 （95%CI:0.926~0.981）。结论 三者对结直肠癌诊断价值由高至低依次为TAP＞CEA＞CA19-9，TAP联合CEA、CA19-9检测能提高检测效能。
Abstract:Objective To investigate the value of tumor abnormal protein (TAP), carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 in the diagnosis of colorectal cancer. Methods A total of 121 patients with colorectal cancer hospitalized in Suzhou Municipal Hospital from December 2018 to December 2021 were selected as experimental group, and 124 healthy people in the same period as control group. The levels of TAP, CEA and CA19-9 in peripheral blood of the two groups were compared. The positive rates of the three indexes in the experimental group were classified and counted according to tumor TNM stage. The receiver operating characteristic curve (ROC) was drawn to compare the diagnostic value of TAP, CEA and CA19-9 alone and in combination in colorectal cancer. Results The positive rates and levels of TAP, CEA and CA19-9 in the experimental group were significantly higher than those in the control group （P<0.01). The total positive rate of TAP in the experimental group (76.03%) was higher than that of CEA (46.28%) and CA19-9 (21.49%) （P<0.01). The positive rates of TAP in patients with different stages were significantly higher than those of CEA and CA19-9 in corresponding stages, and the positive rates of CEA in patients with stage Ⅱ were higher than that of CA19-9. The area under ROC curve (AUC) of TAP ［0.930 (95%CI: 0.897-0.964)］ was significantly higher than that of CEA ［0.795 (95%CI: 0.740-0.850)］ and CA19-9 ［0.642 (95%CI: 0.572-0.711)］, respectively. The AUC of TAP+CEA and TAP+CEA+CA19-9 was the highest, both of which were 0.953 (95%CI: 0.926-0.981). Conclusion The diagnostic value for colorectal cancer is TAP>CEA>CA19-9. TAP combined with CEA and CA19-9 can improve the detection efficiency.
keywords: Tumor abnormal protein Carcinoembryonic antigen Carbohydrate antigen 19-9 Colorectal cancer Clinical diagnosis
文章编号： 中图分类号：R735.3+5 文献标志码：A
基金项目:
| Author Name | Affiliation |
| YUAN Ren-shun, SHI Hai-hua | Gusu School of Nanjing Medical University, Suzhou, Jiangsu 215001, China |
| 施海华1，2 | 1. 南京医科大学姑苏学院，江苏 苏州 215001；2. 南京医科大学附属苏州医院 苏州市立医院胃肠外科，江苏 苏州 215001 |
| Author Name | Affiliation |
| YUAN Ren-shun, SHI Hai-hua | Gusu School of Nanjing Medical University, Suzhou, Jiangsu 215001, China |
| 施海华1，2 | 1. 南京医科大学姑苏学院，江苏 苏州 215001；2. 南京医科大学附属苏州医院 苏州市立医院胃肠外科，江苏 苏州 215001 |
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