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Received:January 19, 2022 Published Online:June 20, 2022
Received:January 19, 2022 Published Online:June 20, 2022
中文摘要: 目的 观察地衣芽孢杆菌治疗儿童抗生素相关性腹泻(AAD)的临床疗效及其对炎症因子和免疫功能的影响。方法 选取2020年9月至2021年8月安徽省妇幼保健院收治的呼吸道感染合并AAD的患儿100例，按照随机数字表法分为对照组和观察组各50例。对照组予常规治疗，观察组在对照组的基础上给予地衣芽孢杆菌治疗，5～7 d为1个疗程。比较两组患儿治疗前后血清炎症因子［肿瘤坏死因子(TNF)-α、白细胞介素（IL）-6、 IL-10］、免疫因子［免疫球蛋白(Ig)A、IgG、IgM］和外周血淋巴细胞亚群（CD3+、CD4+、CD8+和CD4+/CD8+）水平变化及临床疗效。结果 治疗后，观察组治疗总有效率显著高于对照组（88.0% vs 68.0%，χ2=5.828,P＜0.05）。两组患儿血清TNF-α、IL-6水平较治疗前下降，且观察组低于对照组(P＜0.05)；IL-10水平较治疗前上升，且观察组高于对照组(P＜0.05)。两组患儿IgA、IgG、IgM、CD3+、CD4+水平和CD4+/CD8+均较治疗前升高，且观察组高于对照组(P＜0.05)；CD8+水平较治疗前下降，且观察组低于对照组 (P＜0.05)。两组均未见明显不良反应。结论 地衣芽孢杆菌治疗儿童AAD可减轻机体炎症反应，改善免疫功能，临床效果显著且安全性高。
Abstract:Objective To explore the clinical efficacy of Bacillus licheniformis in the treatment of children with antibiotic-associated diarrhea (AAD) and its influences on inflammatory factors and immune function. Methods From September 2020 to August 2021, 100 children with respiratory tract infection complicated with AAD admitted to Anhui Maternal and Child Health Hospital were randomly divided into control group and observation group (n=50, each). The conventional treatment was given in control group, and Bacillus licheniformis was additionally given in observation group based on the routine treatment, which lasted for 5-7 days (a course of treatment). The changes of serum inflammatory factors ［tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-10］, immune factors ［immunoglobulin (Ig) A, IgG, IgM］ and peripheral blood lymphocyte subsets (CD3+, CD4+ and CD4+/CD8+) were observed before and after treatment, and the clinical efficacy was compared between two groups. Results After treatment, the total effective rate in observation group was significantly higher than that in control group (88.0% vs 68.0%, χ2=5.828, P<0.05). Compared with those before treatment, the serum levels of TNF-α and IL-6 decreased after treatment in two groups, and they were significantly lower in observation group than those in control group (P＜0.05). The serum IL-10 level increased after treatment in both groups, and it was significantly higher in observation group than that in control group(P＜0.05). The levels of IgA,IgG,IgM,CD3+,CD4+ and CD4+/CD8+ increased after treatment in both groups, and they were significantly higher in observation group than those in control group(P＜0.05). The level of CD8+ decreased compared with that before treatment in two groups, and it was significantly lower in observation group than that in control group(P＜0.05). No obvious adverse reaction was observed in two groups. Conclusion In the treatment of children with antibiotic-associated diarrhea, Bacillus licheniformis can reduce the inflammatory response and improve immune function. The clinical effect is significant with high safety.
keywords: Antibiotic associated diarrhea Bacillus licheniformis Inflammatory factors Immune function
文章编号： 中图分类号：R725.7 文献标志码：A
基金项目:安徽省妇幼健康科研课题(2020FY06)
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