Abstract:ObjectiveTo study the effects of knowledge attitude belief practice-health belief model (KAP-HBM) combined intervention mode on compliance and psychological status of patients received colonoscopy. Methods A total of 102 patients received colonoscopy for the first time in the hospital were enrolled between August 2020 and May 2021, including 51 cases received routine nursing in control grouPand other 51 cases received KAP-HBM combined nursing in observation group. The cognition degree of intestinal preparation knowledge, compliance, occurrence of adverse reactions, changes of psychological status and scores of patients satisfaction were compared between the two groups. Results After intervention, the awareness score of bowel preparation related knowledge, bowel preparation compliance performance score and patient satisfaction score in the observation grouPwere higher than those in the control grouP(P<0.01); the incidence of adverse reactions in the observation grouPduring the inspection was lower than that in the control grouP(5.88% vs 19.61%, P<0.05); the anxiety and depression scores in the observation grouPwere lower than those in the control grouP(P<0.01). Conclusions KAP-HBM combined intervention mode is beneficial to improve cognition to intestinal preparation knowledge, relieve anxiety and depression, improve compliance and reduce the occurrence of adverse reactions in patients undergoing colonoscopy, with high patients satisfaction.