Abstract:Diabetic nephropathy is one of the most serious microvascular complications of diabetes and is another serious chronic disease following cardiovascular disease and cancer that threatens people's life and health and affects the quality of life. It is very important to deepen the understanding of its pathogenesis and explore new treatment strategies. A large number of studies have shown that silent information regulator 6(SIRT6) is closely related to the improvement of high glucose-induced renal injury, and the possible mechanism is to improve renal function by resisting podocyte injury, renal inflammation and fibrosis. This article briefly summarizes the relevant mechanism of SIRT6 in improving diabetic nephropathy.