Abstract:Objective To evaluate the clinical efficacy of caudal approaches (CA) and intermediate approaches (IA) in laparoscopic radical resection of right colon cancer by Meta-analysis. Methods A comprehensive literature search was conducted by using CNKI, Wanfang Data, PubMed, Embase and Cochrane Library to collect the literatures on the clinical efficacy of two different surgical approaches in laparoscopic radical resection of right colon cancer at home and abroad. Results A total of 1043 patients were enrolled in 12 literatures, including 522 cases in CA group and 521 cases in IA group. The analysis results showed that the operation time (WMD＞=-26.14,95%CI＞:-34.38--17.90), operative blood loss (WMD＞=-13.42,95%CI＞:-17.35--9.50), rate of conversion to laparotomy (OR＞=0.17,95%CI＞:0.08-0.36) and postoperative complication rate (OR＞=0.49,95%CI＞:0.35-0.68) in CA group significantly decreased compared with those in IA group (P<0.01). There was no significant difference in the number of lymph nodes resection and post-operative anal exhaust time between two groups(P>0.05). Conclusion For laparoscopic radical resection of right colon cancer, CA is safe and feasible with good short-term curative effect. Compared with the IA, it has the advantages of shorter operation time, less intraoperative bleeding and lower rates of conversion to laparotomy and lower rate of post-operative complication.