Abstract:Objective To investigate the efficacy and adverse reactions of Chaihu Shugan Powder combined with Banxia Xiexin Decoction in the treatment of chronic atrophic gastritis. Methods From January 2019 to March 2021, 120 patients with chronic atrophic gastritis in Nanjing Jiangbei Hospital were selected as the research objects, and randomly divided into two groups, 60 cases in control group and 60 cases in observation group. The control group was treated with ribavirin, and the observation group was treated with Chaihu Shugan powder and Banxia Xiexin Decoction on the basis of ribavirin. The total effective rate, symptom score, gastric mucosa atrophy score, serum inflammatory factor index, mental state score, score of life quality and incidence of adverse reactions were compared between the two groups. Results The total effective rate of observation group was slightly higher than that of control group, but the difference was not statistically significant (98.33% vs 88.33%, P>0.05). After treatment, stomach pain, belching and acid reflux, poor appetite and appetite, nausea and vomiting, gastric mucosal atrophy score, serum CRP, IL-6, PCT levels, anxiety and depression scores decreased, quality of life scores increased in two goups, and were better in observation group than those in control group(P<0.05). Conclusions Chaihu Shugan Powder combined with Banxia Xiexin Decoction can effectively relieve the symptoms of patients with chronic atrophic gastritis, reduce the degree of gastric mucosa atrophy and inflammatory reaction, and has good curative effect, and can also improve patients psychological state and quality of life. Besides, the adverse reactions do not increase after combined use, and the safety is good.