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Received:September 02, 2021 Published Online:November 20, 2021
Received:September 02, 2021 Published Online:November 20, 2021
中文摘要: 目的 探讨柴胡疏肝散联合半夏泻心汤治疗慢性萎缩性胃炎的疗效及不良反应。方法 于2019年1月至2021年3月,选择南京江北医院肝胃不和型慢性萎缩性胃炎患者120例为研究对象,采取随机数字表法分为对照组和观察组,各60例。对照组单用瑞巴派特治疗,观察组在瑞巴派特基础上采用柴胡疏肝散、半夏泻心汤治疗。比较两组患者的总有效率、症状评分、胃黏膜萎缩评分、血清炎症因子指标、心理状态评分、生活质量评分、不良反应发生率。结果 观察组总有效率稍高于对照组,但差异无统计学意义(98.33% vs 88.33%, P>0.05);治疗后,两组胃脘胀痛、嗳气反酸、食少纳差、恶心呕吐等症状评分,胃黏膜萎缩评分,血清CRP、IL-6、PCT水平,焦虑、抑郁评分降低,生活质量评分增加,且观察组优于对照组(P<0.05)。结论 采用柴胡疏肝散与半夏泻心汤联合用于肝胃不和型慢性萎缩性胃炎患者,可有效缓解患者症状,减轻胃黏膜萎缩程度和炎症反应,具有良好的疗效;还可改善患者心理状态和生活质量,且联合用药后不良反应未增多,安全性良好。
Abstract:Objective To investigate the efficacy and adverse reactions of Chaihu Shugan Powder combined with Banxia Xiexin Decoction in the treatment of chronic atrophic gastritis. Methods From January 2019 to March 2021, 120 patients with chronic atrophic gastritis in Nanjing Jiangbei Hospital were selected as the research objects, and randomly divided into two groups, 60 cases in control group and 60 cases in observation group. The control group was treated with ribavirin, and the observation group was treated with Chaihu Shugan powder and Banxia Xiexin Decoction on the basis of ribavirin. The total effective rate, symptom score, gastric mucosa atrophy score, serum inflammatory factor index, mental state score, score of life quality and incidence of adverse reactions were compared between the two groups. Results The total effective rate of observation group was slightly higher than that of control group, but the difference was not statistically significant (98.33% vs 88.33%, P>0.05). After treatment, stomach pain, belching and acid reflux, poor appetite and appetite, nausea and vomiting, gastric mucosal atrophy score, serum CRP, IL-6, PCT levels, anxiety and depression scores decreased, quality of life scores increased in two goups, and were better in observation group than those in control group(P<0.05). Conclusions Chaihu Shugan Powder combined with Banxia Xiexin Decoction can effectively relieve the symptoms of patients with chronic atrophic gastritis, reduce the degree of gastric mucosa atrophy and inflammatory reaction, and has good curative effect, and can also improve patients psychological state and quality of life. Besides, the adverse reactions do not increase after combined use, and the safety is good.
keywords: Chronic atrophic gastritis Liver-stomach disharmony Chaihu Shugan Powder Banxia Xiexin Decoction
文章编号: 中图分类号:R573.32 R259 文献标志码:B
基金项目:南通大学临床医学专项课题(2019LY024)
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