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Received:March 01, 2021 Published Online:November 20, 2021
Received:March 01, 2021 Published Online:November 20, 2021
中文摘要: 目的 探讨氨肽酶P2(XPNPEP2)表达水平对乳腺癌患者远期预后的影响。方法 研究病例为首都医科大学附属复兴医院2013年1月至2015年6月收治的采用手术治疗的93例乳腺癌患者,收集其手术切除的乳腺癌及癌旁组织的病理标本及临床病理资料。采用免疫组化法检测并比较乳腺癌及癌旁组织XPNPEP2的表达情况,分析其与乳腺癌相关病理参数间的关系;比较不同XPNPEP2表达乳腺癌患者的5年生存率;COX多因素比例风险回归分析乳腺癌预后与XPNPEP2表达的关系。结果 XPNPEP2在乳腺癌组织中阳性表达率72.73%,显著高于癌旁组织中的26.14%(χ2 =38.209,P<0.01)。在乳腺癌组织中,XPNPEP2的阳性表达在不同肿瘤分化程度、淋巴结有无转移及不同TNM分期患者间差异均有统计学意义(P<0.05,P<0.01)。XPNPEP2阳性表达患者5年总生存率35.94%,显著低于阴性表达患者的79.17%(χ2=13.074,P<0.01)。COX回归分析发现,XPNPEP2高表达(HR=3.476,95%CI=1.531~7.892,P<0.01)、肿瘤分化程度低(HR=2.903,95%CI=1.357~6.210,P<0.01)、淋巴结发生转移(HR=3.415,95%CI=1.167~9.992,P<0.05)及TNM分期高(HR=2.767,95%CI=1.125~6.803,P<0.05)均是影响乳腺癌患者预后的独立危险因素。结论 XPNPEP2的阳性表达与乳腺癌患者多种病理参数及不良预后相关,有望成为其预后评估的潜在标志物。
Abstract:Objective To investigate the effect of X-prolyl aminopeptidase P2 (XPNPEP2) level on the long-term prognosis of patients with breast cancer. Methods The pathological specimens of breast cancer tissues and paracancerous tissues and the clinicopathological data were collected from 93 patients with breast cancer undergoing surgical treatment from January 2013 to June 2015. The expressions of XPNPEP2 were detected by immunohistochemistry and compared between breast cancer tissues and adjacent tissues, analyze the relationship between the expression of XPNPEP2 and the pathological parameters of breast cancer. The 5 year- survival rate associated with different XPNPEP2 expression levels was compared. The relationship between prognosis of breast cancer and expression of XPNPEP2 was analyzed by COX multivariate proportional hazards regression. Results The positive expression rate of XPNPEP2 in breast cancer tissues was significantly higher than that in adjacent tissues (72.73% vs 26.14%, χ2=38.209,P<0.01). The positive expressions of XPNPEP2 were significantly related with the tumor differentiation, lymph node metastasis and TNM stages in breast cancer tissues(P<0.05,P<0.01). The 5-year overall survival rate of patients with XPNPEP2 positive expression was significantly lower than that of patients with XPNPEP2 negative expression(35.94% vs 79.17%, χ2=13.074,P<0.01). COX regression analysis showed that high XPNPEP2 expression (HR=3.476, 95%CI=1.531-7.892,P<0.01), poor tumor differentiation (HR=2.903, 95%CI=1.357-6.210,P<0.01), lymph node metastasis (HR=3.415, 95%CI=1.167-9.992,P<0.05) and high TNM stage (HR=2.767, 95%CI=1.125-6.803,P<0.05) were the independent risk factors affecting the prognosis of breast cancer patients. Conclusion The positive expression of XPNPEP2 is associated with a variety of pathological parameters and poor prognosis and is expected to be a potential marker for prognosis evaluation in breast cancer patients.
文章编号: 中图分类号:R737.9 文献标志码:A
基金项目:
Author Name | Affiliation |
ZHANG Quan-wen, YANG Qi, GE Sha-sha | Department of General Surgery, Fuxing Hospital Affiliated to Capital Medical University, Beijing 100038, China |
Author Name | Affiliation |
ZHANG Quan-wen, YANG Qi, GE Sha-sha | Department of General Surgery, Fuxing Hospital Affiliated to Capital Medical University, Beijing 100038, China |
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