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Received:March 22, 2021 Published Online:November 20, 2021
Received:March 22, 2021 Published Online:November 20, 2021
中文摘要: 目的 探讨血栓标志物凝血酶抗凝血酶复合物(TAT)、纤溶酶-α2纤溶酶抑制剂复合物(PIC)、可溶性血栓调节蛋白(sTM)及组织纤溶酶原激活物-抑制剂复合物(t-PAIC)对慢性阻塞性肺疾病(COPD)合并深静脉血栓形成(DVT)的诊断价值。方法 回顾性分析攀枝花市中心医院重症医学科2020年2月至2021年2月收治的173例COPD患者的临床资料,根据是否合并DVT将患者分为血栓组(53例)和非血栓组(120例), 并将50例同期健康体检者作为对照组,检测各组血栓标志物TAT、PIC、sTM和t-PAIC水平,并对其诊断COPD合并DVT效能进行ROC曲线分析。结果 血栓组的TAT、PIC、sTM及t-PAIC水平均高于非血栓组和对照组,非血栓组PIC、sTM及t-PAIC水平高于对照组,差异有统计学意义(P<0.01)。ROC曲线显示,TAT诊断COPD合并DVT曲线下面积(AUC)(0.794)及特异度(80.6%)最高,PIC灵敏度(81.9%)最高,TAT联合PIC诊断灵敏度(82.4%)和特异度(81.5%)高于单一诊断,AUC最大(0.904)。结论 TAT、PIC、sTM、t-PAIC对COPD患者合并DVT均有一定诊断价值,但联合TAT与PIC的诊断价值更高。
Abstract:Objective To investigate the diagnostic value of thrombin-antithrombin complex(TAT), plasmin-α2-plasmin inhibitor complex(PIC), soluble thrombomodulin(sTM) and tissue plasminogen activator inhibitor complex (t-PAIC) in patients with chronic obstructive pulmonary disease (COPD) complicated with deep vein thrombosis(DVT). Methods Retrospective analysis was performed on 173 COPD patients admitted to the ICU of Panzhihua Central Hospital from February 2020 to February 2021. The patients were divided into thrombotic group (53 cases) and non-thrombotic group (120 cases) according to whether they had DVT, and 50 healthy subjects were selected as control group. The level of TAT, PIC, sTM and t-PAIC were analyzed and ROC curve was further analyzed. Results The levels of TAT, PIC, sTM and t-PAIC in the thrombus group were higher than those in the non-thrombus group and the control group, the levels of PIC, sTM and t-PAIC in the non-thrombus group were higher than those in the control group, the difference was statistically significant (P<0.01). The ROC curve showed that for single thrombus marker detection, TAT had the highest diagnostic AUC (0.794) and specificity (80.6%), PIC had the highest sensitivity (81.9%). The sensitivity (82.4%) and specificity (81.5%) and AUC (0.904) of TAT combined with PIC were higher than those of single diagnosis. Conclusion TAT, PIC, sTM, t-PAIC have certain diagnostic value for COPD patients with DVT, and the combination of TAT and PIC have higher diagnostic value.
keywords: Chronic obstructive pulmonary disease Thrombin-antithrombin complex Plasmin-α2-plasmin inhibitor complex Soluble thrombomodulin Tissue plasminogen activator inhibitor complex Deep vein thrombosis
文章编号: 中图分类号:R563.9 R543.6 文献标志码:A
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