Abstract:Objective To investigate the efficacy and safety of dexmedetomidine and oxycodone during drug-coated balloon (DCB) interventional anesthesia in patients with lower extremity arteriosclerosis obliterans complicated with heart failure（HF）. Methods The patients with superficial femoral artery occlusion complicated with HF treated with DCB therapy from May 2015 to May 2019 were randomly divided into experimental group (dexmedetomidine with oxycodone, n =63) and control group (fentanyl with dexmedetomidine, n =63). MAP, HR and SpO2 in perioperative period ［ten minutes before catheterization (T1), after femoral artery puncture (T2), completion of balloon dilatation (T3), withdrawal of guide wire and indwelling of sheath (T4)］, operation condition, adverse reaction and evaluation of lower limb ischemia 6 months after operation were observed between two groups. Results MAP, SpO2 and HR changed significantly in T2 and T3, and most of the differences were statistically significant compared with T1 ( P <0.05). Except for MAP of T3, there were significant differences in MAP, SpO2 and HR between the two groups at T2 and T3 ( P <0.05). VAS score in experimental group was better than that in control group, and the recovery time of consciousness after operation was significantly shorter than that in control group( P <0.01). During 6 months of follow-up after operation, ankle-brachial index (ABI) was higher than that before treatment in both groups and was higher in experimental group than that in control group ( P <0.01). There was no statistical difference in the total operation time, Ramsay sedation score, NT-proBNP level before and after surgery, and Rutherford grades at 6 months after operation between two groups ( P >0.05). Conclusions In the perioperative period of DCB therapy,the anesthesia effect of oxycodone and dexmedetomidine is exact and can obviously reduce operative pain and have no negative impacts on cardiac function and 6-month lower limb ischemia.