Abstract:Objective To explore the accuracy and value of tremor analysis in differential diagnosis of essential tremor and Parkinsons disease. Methods Eighty-eight patients with limb tremor treated from January 2018 to January 2021 were selected for tremor analysis and midbrain sonography. Based upon the Results of comprehensive clinical examination, the diagnostic efficacy of tremor analysis and midbrain sonography were compared in diagnosing essential tremor and Parkinsons disease. Results Among 88 patients with unilateral limb tremor, there were 47 cases of Parkinsons disease, 30 cases of primary tremor and 11 cases of non-primary tremor and non-Parkinsons disease confirmed by clinical comprehensive diagnosis. The specificity, accuracy and positive predictive value by tremor analysis in the diagnosis of Parkinsons disease, and the sensitivity, specificity, accuracy, positive predictive value and negative predictive value by tremor analysis in the diagnosis of essential tremor were higher than those by midbrain ultrasonography ( P <0.05, P <0.01). The consistency test showed the higher consistency between tremor analysis and clinical comprehensive examination. The tremor frequency of patients with Parkinsons disease was lower than that of patients with essential tremor ( P <0.01), and the proportion of tremor alternating contraction was higher than that of patients with essential tremor（ P <0.01）. Conclusion Tremor analysis can accurately differentiate Parkinsons disease from essential tremor, and has good diagnostic value.