Abstract:Objective To investigate the efficacy and safety of traditional treatment combined with early blood purification in the treatment of children with fulminant myocarditis. Methods A retrospective analysis was performed on nine children with fulminant myocarditis, who were treated with blood purification. All patients were examined by ECG, echocardiography, myocardial enzymes,and so on. The biochemical indicators, including myocardial enzymes, troponin I, proBNP, liver and kidney function and coagulation function were monitored before and after blood purification. Results One patient died，and eight patients survived. After treatment, the levels of creatine kinase (CK), creatine kinase myocardial band (CK-MB), troponin I, proBNP, lactate dehydrogenase (LDH) and AST were significantly lower than those before treatment in 8 cases (P<0.05). Before treatment, liver and kidney function damage in different degrees occurred in 5 cases and were significantly improved after blood purification treatment. There were 1 case of a little bleeding at the catheter site and 1 case of filter coagulation, and no deep vein thrombosis or catheter-related bloodstream infection occurred during blood purification treatment.