Abstract:Objective To investigate the willingness and influencing factors to receive coronavirus disease 2019 (COVID-19) vaccination in the patients with chronic kidney disease (CKD) to provide reference for clinical health education. Methods From Janvary 6 to 24,2021, a questionnaire survey was performed to investigate the intention to receive COVID-19 vaccination and identify the key influencing factors of 301 CKD patients selected by a convenient sampling method in outpatient and inpatient wards of a level-A tertiary hospital in Chengdu. Spearman′s rank correlation test was used to explore the associations of COVID-19 vaccination willingness of CKD patients with age, gender, family monthly income per capita, employment status, perceived susceptibility, perceived barriers, perceived severity and action clues, etc. Multi-stratified multiple regression test was used to analyze the influencing factors of COVID-19 vaccination willingness in CKD patients. Results The mean value of quartile of willingness to vaccinate was 4（inter quartile range 2-5) in CKD patients. The influencing factors of COVID-19 vaccination willingness included complications (P<0.01), knowledge of contraindications to vaccination (P<0.05), perceived susceptibility (P<0.05), perceived barriers (P<0.01) and action clues (P=0.01). Conclusion The COVID-19 vaccination willingness is moderate in CKD patients. Medical staff should conduct the health education in clinical practice focusing on the susceptibility of patients and the benefits of COVID-19 vaccination so as to increase the patients′ willingness to receive the COVID-19 vaccination.