Abstract:Objective To explore the influences of pregnancy complicated with systemic lupus erythematosus (SLE) on pregnancy outcome and analyze the risk factors of pregnancy loss (abortion,stillbirth) and adverse fetal outcome (premature birth or fetal growth restriction). Methods A retrospective analysis was performed on 57 pregnancies in 54 pregnant SLE women with complete data of prenatal examination and delivery from March 1,2012 to December 31,2019 in the First Affiliated Hospital of Guangzhou University of TCM.According to SLE disease activity index (SLEDAI),there were 32 active SLE pregnant women (34 pregnancies) in first-trimester(active group) and 22 stable SLE pregnant women (23 pregnancies) in first-trimester(inactive group). Results The incidences of pregnancy loss (including abortion,stillbirth),preeclampsia,lupus nephritis and adverse fetal outcome were 29.41%,35.29%,67.65% and 29.41%,respectively in active group and were significantly higher than those (0%,4.35%,4.35% and 4.35%,respectively) in inactive group(P<0.05,P<0.01).Logistic regression analysis showed that higher SLEDAI score in first-trimester(OR=1.322,P=0.027) and positive anti-SSB antibody(OR=5.315,P=0.045) were the independent risk factors for pregnancy loss,and lupus nephritis (OR=29.603,P=0.011) was an independent risk factor for adverse fetal outcome. Conclusions SLE disease activity in early pregnant women can increase the incidences of pregnancy loss,preeclampsia,lupus nephritis and adverse fetal outcome,and is closely related to pregnancy loss.Lupus nephritis is closely related to adverse fetal outcome.