Abstract:Objective To investigate the clinical features and prognosis of metastatic carcinoma to the spleen (MCS). Methods A retrospective analysis was performed on the clinical data of 41 MCS patients from January 2013 to May 2019 in Shaanxi Provincial Cancer Hospital.The clinical characteristics,imaging features,treatment and prognosis of patients were analyzed. Results In 41 patients with MCS,there were 24 males and 17 females,with an average age of (58.49±10.95)years old.Lung cancer was the most common primary tumor,followed by gastric cancer,ovarian cancer and colorectal cancer,etc.The clinical detection rate of CT,MRI and PET-CT was 100% for the diagnosis of MCS.Palliative chemotherapy was the main treatment methord for MCS as an advanced tumor and was conducted depending on its pathological type.However,surgery was performed for solitary spleen metastasis.The median follow-up time of the patients was 10.6 months,the median survival duration was 8.9 months,and the one-year survival rate was 45.7%. Conclusions The incidence of MCS is low,with no specific clinical manifestations.CT and MRI are the first line imaging examinations for MCS.Early solitary MCS is mainly treated by surgery,and the patients with MCS accompanied by other organ metastases should be treated with chemotherapy.