Abstract:Objective To investigate the effects of cervical loop electrosurgical excision procedure (LEEP) and cervical cold knife conization (CKC) on the pregnancy outcome of patients with high-grade cervical intraepithelial neoplasia (CIN) and to provide reference for clinical treatment.Methods A retrospective analysis was performed on the clinical data of 81 patients with pregnancy intention after LEEP or CKC for high-grade CIN from January 2015 to December 2018.The patients were divided into LEEP group (n=41) and CKC group (n=40) according to the operation methods.The pregnancy rate,abortion rate,premature birth rate,premature rupture of membranes,low birth weight infants,cesarean section rate were analyzed and compared between two groups.Results There was no significant difference in pregnancy rate between LEEP group and CKC group (90.2% vs 87.5%,P>0.05).The incidence of abortion rate (16.2% vs 37.1%),premature birth rate (5.4% vs 25.7%),low birth weight infants rate (8.1% vs 28.6%),and uterine delivery rate (13.5% vs 42.9%) in LEEP group were significantly lower than those in CKC group (P<0.05 ,P<0.01 ).Conclusions The incidences of abortion,premature birth,low birth weight and cesarean section in patients with CKC are significantly higher than those in patients with LEEP.For the patients with fertility requirements after being with high-grade cervical intraepithelial neoplasia,LEEP treatment can be preferred.