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Received:November 24, 2020 Published Online:May 20, 2021
Received:November 24, 2020 Published Online:May 20, 2021
中文摘要: 目的 对急性脑梗死患者联合使用奥扎格雷和红花注射液的疗效和安全性进行分析并评价。方法 计算机检索1989年至2020年Medline、PubMed、Cochrane图书馆、中国生物医学文献数据库、中国知网和万方数据库搜集奥扎格雷和红花注射液治疗急性脑梗死的临床随机对照试验,对符合纳入标准的文献采用Review Manager 5.1软件统计并分析数据。结果 共纳入22项研究。对照组样本量1 239例,应用丹参或复方丹参注射液、血塞通注射液、川芎嗪注射液、维脑路通等治疗。联合组共1 252例,采用奥扎格雷联合红花注射液治疗。Meta分析结果显示,联合组神经功能缺损临床疗效(OR=4.43,95%CI:3.44～5.72,P<0.01)、神经功能缺损恢复程度(WMD=-4.69,95%CI:-5.06～-4.31,P<0.01)优于对照组。22项研究中7项发生不良反应,均为头痛、恶心、食欲不振等轻微症状,及时处理后均消失。联合组和对照组不良反应发生率比较差异无统计学意义(P>0.05)。结论 奥扎格雷和红花注射液联合治疗急性脑梗死安全、有效,可显著改善患者的神经功能缺损情况。
Abstract:Objective To evaluate the curative effect and safety of ozagrel combined with safflower injection in the treatment of patients with acute cerebral infarction (ACI).Methods The randomized controlled trials (RCTs) of ozagrel and safflower injection in the treatment of ACI were collected by electronic searches of Medline,PubMed,Cochrane Library,China Biology Medicine disc,China National Knowledge Infrastructure and Wanfang Database from 1989 to 2020.Data analysis of literatures meeting the inclusion criteria was performed with the Review Manager 5.1 software.Results There were 22 literatures which corresponded with the criterion were homogenous,involving 1 239 cases in control group and 1 252 cases in combination group.Salvia miltiorrhiza compound injection,Xuesaitong injection,Ligustrazine injection or venoruton were given in control group,and ozagrel combined with safflower injection was used in combination group.Meta-analysis showed that the clinical efficacy (OR=4.43,95%CI:3.44-5.72,P<0.01 ) and the recovery of neurological deficit (WMD=-4.69,95%CI:-5.06- -4.31,P<0.01 )in combination group were significantly better than those in control group.In 22 RTCs,adverse reactions,including headache,nausea,loss of appetite and other mild symptoms were found in 7 RTCs and disappeared after timely treatment.There was no significant difference in the incidence of adverse reactions between two groups (P>0.05).Conclusion In the treatment of acute cerebral infarction,ozagrel combined with safflower injection is safe and effective and can obviously improve the neurological function of ACI patients.
文章编号： 中图分类号：R743.3 文献标志码：A
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