Abstract:Objective To investigate the relationship between serum plasminogen activator inhibitor 1(PAI-1) and imaging of steroid (glucocorticoid)-induced onecrosis of femoral head (SONFH) in different X-ray imaging stages and their significance. Methods A total of 75 SONFH patients treated at Pizhou Hospital Affiliated to Xuzhou Medical University from June 2018 to May 2019 were selected as observation group,including 25 cases of stage Ⅱ,25 cases of stage Ⅲ and 25 cases of stage Ⅳ based on Association Research Circulation Osseous(ARCO) staging.During the same period,75 healthy persons were randomly selected as control group.The serum PAI-1 levels were detected by enzyme-linked immunosorbent assay (ELISA) and compared between two groups. Results The serum PAI-1 level in observation group was significantly higher than that in control group ［(21.87±2.39) mg/L vs (12.52±1.22) mg/L,P<0.05］.However,there were no significant differences in serum PAI-1 level among SONFH patients with different imaging stages(including no collapse and collapse of femoral head) (all P>0.05). Conclusions In the patients with SONFH,the serum PAI-1 level increases significantly,which can be used as a reference index for clinical diagnosis and treatment of SONFH.However,PAI-1 level is not obviously correlated with X-ray imaging staging and femoral head collapse or not.