Abstract:Objective To investigate the associations of serum ischemia modified albumin (IMA) and central nerve specific protein (S100B) with the disease condition and the predictive values for prognosis in patients with aneurysmal subarachnoid hemorrhage (aSAH). Methods A total of 191 patients with aSAH from January 2016 to September 2019 were selected for retrospective study.According to the modified Rankin scale (mRS) at 6 months after operation,the patients were divided into good prognosis group(n=138) and poor prognosis group(n=53).The serum levels of IMA and S100B were detected,and the associations of them with the pathological features of aSAH were analyzed.By drawing the receiver operating characteristic(ROC) curve,the prognostic value of IMA and S100B was analyzed in patients with aSAH. Results The serum levels of IMA and S100B were statistically correlated to the presence or sbsence of ventricular hematocele,Hunt-Hess grading and Fisher grading scales at admission (all P<0.01),and were not associated to age,sex,aneurysm location and size,and history of hypertension or diabetes (all P>0.05).The incidence of non-ventricular hematocele,Hunt Hess grade Ⅰ-Ⅱ and Fisher grade Ⅰ-Ⅱ in patients with good prognosis were higher than those in patients with poor prognosis,while the serum IMA and S100B levels were significantly lower than those in patients with poor prognosis (all P<0.01).In evaluating the prognosis of aSAH by combined detection of IMA (optimal critical value=56.36 U/ml) and S100B (optimal critical value=0.84 ng/ml),the area under ROC curve(AUC) was 0.942,with a sensitivity of 84.9%,and a specificity of 92.8%.Ventricular hematocele,high Hunt-Hess grading,high Fisher grading and high serum IMA and S100B levels were the independent risk factors for poor prognosis of aSAH patients(P<0.05,P<0.01). Conclusion Serum IMA and S100B levels are related to the severity of aSAH,and detection of them is helpful to evaluate the prognosis of aSAH patients.