Abstract:Objective To explore the independent risk factors for the portal venous thrombosis (PVT) in liver cirrhosis and establish a non-invasive predictive model with high practicability and wide applicability in order to provide a foundation for the prevention and therapy of PVT in liver cirrhosis. Methods A retrospective analysis was performed on 353 patients with liver cirrhosis,who were hospitalized in the Affiliated Hospital of Southwest Medical University from September 2018 to April 2020 and met the inclusion criteria.Among them,60 patients with PVT were designed as experimental group,and 120 patients without PVT were randomly selected as control group.Based on the factors possiblly affecting the formation of PVT by univariate analysis and multivariate logistic regression analysis,a noninvasive prediction model of PVT in cirrhosis was established. Results The leading causes of cirrhosis were hepatitis virus and alcoholism,accounting for 63.89% and 16.28% respectively.Hepatitis B was the most important cause of cirrhosis,accounted for 57.78%.Multivariate logistic regression analysis showed that decreased hemoglobin(Hb) level(OR=0.98,95%CI：0.97-0.99，P<0.01),increased D-dimer level(OR=1.40,95%CI：1.19-1.65,P<0.01)and enlarged splenic vein diameter(OR=15.24,95%CI：3.68-63.13,P<0.01)were the independent risk factors for PVT.The prediction model of PVT formation was established as logit P(PVT)=-2.76+0.34×D2+2.72×spenic vein inner diameter-0.02 × Hb.The incidence of upper gastrointestinal bleeding in PVT group was significantly higher than that in non-PVT group (70.00% vs 37.50%,P<0.001).There were no significant differences in the clinical symptoms and the complications between two groups(P>0.05). Conclusion Hepatitis B is still the main cause of liver cirrhosis,followed by alcohol.The risk of upper gastrointestinal bleeding in PVT patients is significantly increased,which is not conducive to the prevention and treatment of gastroesophageal variceal bleeding.Decreased Hb level,increased D-dimer level and enlarged splenic vein diameter were the independent risk factors for PVT.For these patients,the above indexes should be observed dynamically,and the diagnosis and treatment should be further strengthened if necessary.