Abstract:Objective To investigate the effects of bivalirudin combined with Compound Danshen Dripping Pills (CDDP) on cardiac function and levels of renalase and angiopoietin 2 (Ang-2) in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). Methods A total of 120 patients with AMI in Wanbei Coal and Power Group General Hospital from September 2017 to November 2019 were selected for prospective randomized controlled study.The patients were randomly divided into combination group,control group A and control group B (n=40,each).Based on PCI and routine treatment,during the perioperative period,bivalirudin was given in control group A,CDDP was given in control group B,and bivalirudin combined with CDDP was given in combination group.The indexes of cardiac function［left ventricular ejection fraction (LVEF),left ventricular end systolic diameter (LVESD),left ventricular end diastolic diameter (LVEDD)］,hemorheology indexes(plasma viscosity,low shear whole blood viscosity,high shear whole blood viscosity,hematocrit),serum inflammatory factors［interleukin-6 (IL-6),high sensitivity C-reactive protein (hs-CRP),tumor necrosis factor-α (TNF-α)］,indexes of endothelial cell function［nitrogen oxide (NO),endothelin-1 (ET-1)］and levels of renalase and Ang-2 were compared before PCI and 1 week after PCI among three groups.The patients were followed up for one month to observe the incidence of complications in three groups. Results At one week after PCI,all indicators above mentioned and the levels of renalase and Ang-2 were significantly lower in combination group than those in control group A and control group B except LVEF and NO,which were significantly higher than those in control group A and control group B (P<0.05).There was significant difference in the incidence of complication among three groups (P<0.05). Conclusion Bivalirudin combined with CDDP can improve heart function,hemorheology and vascular endothelial function and inhibit inflammation in AMI patients after PCI.