Abstract:Objective To investigate the relationship between serum uric acid (SUA) level and nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM). Methods A cross-sectional study was conducted in 1 808 patients with T2DM from January 2010 to December 2016.By abdominal ultrasound diagnosis,there were 668 patients in NAFLD group and 1 140 patients in non NAFLD group.According to the quartile of SUA level,the patients were divided into four groups (Q1-Q4),and the relationship between SUA level and metabolic indicators was analyzed. Results The incidence of NAFLD was 36.9%.There were significant differences in age, disease duration,body mass index (BMI), systolic blood pressure (SBP),diastolic blood pressure (DBP), triglyceride (TG), alanine aminotransferase (ALT), aspartate aminotransferase (AST),γ-glutamyl transpeptidase (γ-GT),serum creatinine (SCr), fasting plasma glucose (FPG), fasting C-peptide (FCP),high density liptein cholesterol (HDL-C) and total bilirubin (TBIL) (P<0.05),while there was no significant difference in total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) (P>0.05) among the Q1, Q2, Q3 and Q4 group.The prevalence of NAFLD in men was 13.07%,32.50%,41.71% and 49.75% in group Q1,Q2,Q3 and Q4,respectively (P<0.01).Spearman correlation analysis showed SUA level was significantly positively correlated with BMI,SBP,TG,ALT,AST,γ-GT,SCr and FCP (P<0.01) and was negatively correlated with FPG,HDL-C and TBIL in both genders (P<0.05).Multiple Logistic regression analysis revealed that BMI,TG,ALT,FCP and SUA were the influencing factors for NAFLD(P<0.05). Conclusion SUA is closely related to NAFLD in male patients with T2DM and is an independent risk factor for NAFLD.