Abstract:Objective To study the expressions and significance of serum liver X receptor α(LXRα) and sterol regulatory element binding protein-1c(SREBP-1c) in patients with hypertensive disorder complicating pregnancy.Methods Eighty patients with hypertensive disorder complicating pregnancy receiving treatment from February 2017 to August 2019 were selected,in whom there were 31 cases in pregnancy hypertension group,25 cases in mild preeclampsia group and 24 cases in severe preeclampsia group.At the same time,60 normal pregnant women were served as control group.The general information,blood lipid levels and serum LXRα and SREBP-1c protein expression levels were compared among the four groups.Results There were no significant differences in age,gestational age and pre-pregnancy BMI among four groups(P＞0.05).With the increase of disease severity,systolic blood pressure (SBP),diastolic blood pressure (DBP),24-hour urine protein content,TC,TG,LDL-C and serum levels of LXR α and SREBP-1c gradually increased,and HDL-C gradually decreased( P<0.01).There were statistical differences in pairwise comparison of the indicators among four groups（ P<0.05）.Pearson correlation analysis showed that serum LXRα and SREBP-1c levels were positively correlated with TC,TG and LDL-C and were negatively correlated with HDL-C( P<0.01),and there was a positive correlation between serum LXRα and SREBP-1c( r=0.576, P<0.05).Conclusion In patients with hypertensive disorder complicating pregnancy,LXR α and SREBP-1c are highly expressed and closely related to the severity of the disease,which may be involved in the occurrence and development of the disease by regulating lipid metabolism.