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Received:February 14, 2020 Published Online:December 20, 2020
Received:February 14, 2020 Published Online:December 20, 2020
中文摘要: 目的 观察白头翁汤加减方口服治疗轻、中度溃疡性结肠炎急性发作的临床疗效。方法 选取2017年1月至2019年1月就诊的60例诊断为轻、中度溃疡性结肠炎急性发作(湿热内蕴证)患者,按照随机数字表法,将患者随机分为对照组和试验组各30例;对照组患者予以柳氮磺胺吡啶肠溶片口服,1 g/次,3次/d;试验组患者在对照组基础上,加以白头翁汤加减方口服,3次/d,1天1剂;两组患者均治疗4周,观察两组患者前后症状积分,炎症因子肿瘤坏死因子(TNF)-α、超敏C反应蛋白(hs-CRP)、白细胞介素(IL)-8,以及结肠镜评分、黏膜组织评分、Mayo指数评分。结果 (1)治疗后两组患者主症及次症症状积分、TNF-α、hs-CRP、IL-8、结肠镜评分、黏膜组织评分、Mayo 指数评分与治疗前比较,均有好转,差异有统计学意义(P<0.05);(2)治疗后两组对比,试验组好转程度明显优于对照组,差异有统计学意义(P<0.05);(3)试验组总有效率93.3%,对照组总有效率80.0%,试验组疗效优于对照组,差异有统计学意义(Z=2.075,P<0.05)。结论 白头翁汤加减方口服,能够改善轻、中度溃疡性结肠炎急性发作临床症状、结肠镜下组织形态以及机体炎症反应,提高临床疗效。
Abstract:Objective To observe the clinical effect of Baitouweng decoction in the treatment of acute active stage of mild to moderate ulcerative colitis. Methods Sixty patients with acute episode of mild-to-moderate ulcerative colitis (damp- heat syndrome) were randomly divided into control group and experimental group (n=30, each) according to the random number table method.The sulfasalazine enteric coated tablets (1 g/time, 3 times/day) were orally given in both groups, and modified Baitouweng decoction (3 times one day, one dose per day) was added in experimental group.After treatment for 4 weeks, the symptom scores, inflammatory factors, tumor necrosis factor (TNF)-α, high sensitivity C-reactive protein (hs-CRP), interleukin-8(IL-8), colonoscopy score, mucosal tissue score and Mayo endoscopic score were observed and compared. Results After treatment, main symptom and secondary symptom score, levels of TNF-α, CRP and IL-8, colonoscopy score, mucosal tissue score and Mayo score were statistically better than those before treatment in two groups (P<0.05) and were significantly better in experimental group than those in control group (P<0.05).The total effective rate in experimental group was statistically higher than that in control group (Z=2.075, P<0.05). Conclusion Baitouweng decoction can improve the clinical symptoms, tissue morphology under colonoscopy and body inflammatory reaction in patients with acute active stage of mild to moderate ulcerative colitis.
文章编号: 中图分类号:R256.34,R574.62 文献标志码:B
基金项目:陕西省中医药管理局课题(JCPT050);陕西中医药大学课题(2016PY02)
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